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Prevalence of Human T-Cell Lymphotropic Virus Type I Infection in Singapore: A Preliminary Report

Laboratory of Central Nervous System Studies National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland Department of Community, Occupational and Family Medicine National University of Singapore

Richard Yanagihara, MD

Laboratory of Central Nervous System Studies National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland Department of Community, Occupational and Family Medicine National University of Singapore

Carlos Mora, MD

Laboratory of Central Nervous System Studies National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland Department of Community, Occupational and Family Medicine National University of Singapore

Ralph M Garruto, PhD

Laboratory of Central Nervous System Studies National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland Department of Community, Occupational and Family Medicine National University of Singapore

Tze Wai Wong, MBBS

Laboratory of Central Nervous System Studies National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland Department of Community, Occupational and Family Medicine National University of Singapore

D Carleton Gajdusek, MD

Laboratory of Central Nervous System Studies National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland Department of Community, Occupational and Family Medicine National University of Singapore

Human T-cell lymphotropic virus type i (HTLV-I) infection is endemic in southwestern Japan, the Caribbean basin, Colombia, Africa and in several isolated populations in Papua New Guinea, the Solomon Islands and Vanuatu. To determine the seroprevalence of HTLV-I infection in Singapore, we tested sera from 115 hospitalized patients with acute nephritis, 50 patients with suspected leptospirosis, 34 patients with non-A, non-B hepatitis, and from 28 healthy volunteers for IgG antibodies against HTLV-I using an enzyme-linked immunosorbent assay. Antibodies were detected in sera from 6 of the 199 patients and from 3 of the 28 healthy volunteers, but these positives could not be confirmed by Western immunoblotting. Our data are consistent with other reports of low seroprevalence of HTLV-I infection despite extensive Japanese contact in Korea, Taiwan, the People's Republic of China and Micronesia. Further studies on a larger sample size, however, are necessary to confirm the absence of any focus of infection in the Singapore population.

Key Words: Enzyme immunoassay • HTLV-I • Seroepidemiology • Southeast Asia

Asia-Pacific Journal of Public Health, Vol. 5, No. 3, 236-238 (1991)
DOI: 10.1177/101053959100500308


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